integrin β3 (Santa Cruz Biotechnology)
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Structured Review
Santa Cruz Biotechnology
integrin β3
Integrin β3, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 336 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/integrin+%CE%B23/Integrin+%CE%B23+Antibody/pmc12703868-50-9-16
Average 95 stars, based on 336 article reviews
Integrin β3, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 336 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/integrin+%CE%B23/Integrin+%CE%B23+Antibody/pmc12703868-50-9-16
Average 95 stars, based on 336 article reviews
integrin β3 - by Bioz Stars,
2026-09
95/100 stars
Images
1) Product Images from "Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis"
Article Title: Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis
Journal: Bioactive Materials
doi: 10.1016/j.bioactmat.2025.11.032
Figure Legend Snippet: AZD3965 inhibits key osteoclast marker protein expression in vitro. (A) Protein expression of integrin-β3, NFATc1, MMP9, CTSK and c-Fos detected via Western blotting after 5-day treatment with RANKL and AZD3965 (0, 5, 10 μM). (B–F) Quantification of osteoclast marker protein expression with specified intervention (all normalized to β-actin). (G) NFATc1 expression and nuclear translocation detected via immunofluorescence staining (scale bar = 50 μm). (H) Quantification of NFATc1 mean fluorescence intensity in the nucleus. (I) Protein expression of integrin-β3, NFATc1, MMP9, CTSK and c-Fos detected via Western blotting after treatment with RANKL and AZD3965 at different time points. (J–N) Quantification of osteoclast marker protein expression on the specified day (all normalized to β-actin). N = 3. ##P < 0.01, ###P < 0.001, ####P < 0.0001, compared to control group. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001, compared to the RANKL alone treatment group.
Techniques Used: Marker, Expressing, In Vitro, Western Blot, Translocation Assay, Immunofluorescence, Staining, Fluorescence, Control
Figure Legend Snippet: PH/DPA@A inhibits RANKL-induced osteoclast formation and bone resorption function in vitro. (A) Protein expression of integrin-β3, NFATc1, MMP9, CTSK and c-Fos detected via Western blotting after 5-day treatment with RANKL and PH/DPA@A in five groups. (B–F) Quantification of osteoclast marker protein expression with indicated intervention (all normalized to β-actin). (G) TRAcP staining to assess osteoclast differentiation of BMMs in five groups. (H) Quantification of TRAcP staining in five groups. (I, J) F-actin staining and quantification of F-actin ring area in five groups. (K–L) Bone slice assay using mature osteoclasts and quantification of resorption area in five groups. Scale bar = 200 μm. N = 3. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001.
Techniques Used: In Vitro, Expressing, Western Blot, Marker, Staining
Related Articles
Marker:Article Title: Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis Article Snippet: Cell culture supplies, including α-MEM and fetal bovine serum (FBS), were sourced from Thermo Fisher Scientific in Carlsbad, United States. .. Antibodies against osteoclast marker proteins, such as c-Fos, CTSK, other:Article Title: Extracellular matrix protein signaling promotes multi-step cancer vasculogenic mimicry formation Article Snippet: 3-D Culture Matrix Rat Collagen I (3447-020-01) and 3-D Culture Matrix Laminin I (3446-005-01) were purchased from R&D Systems (Minneapolis, MN). siRNA against Integrin β1 (sc-35674), primary antibodies Integrin β1 (P5D2, sc-13590), Cortactin (H-5, sc-55579) and Article Title: Extracellular matrix protein signaling promotes multi-step cancer vasculogenic mimicry formation. Article Snippet: 3-D Culture Matrix Rat Collagen I (3447-020-01) and 3-D Culture Matrix Laminin I (3446-005-01) were purchased from R&D Systems (Minneapolis, MN). siRNA against Integrin β1 (sc-35674), primary antibodies Integrin β1 (P5D2, sc-13590), Cortactin (H-5, sc-55579) and Incubation:Article Title: Bone-on-a-chip recapitulates dynamic bone remodeling. Article Snippet: Bone remodeling is governed by the basic multicellular unit (BMU) and plays a crucial role in both normal bone function and pathological conditions (e.g. osteoporosis).. Unfortunately, our understanding of the bone remodeling process is limited as current models do not allow dynamic events in the BMU to be systematically and spatiotemporally analyzed.. Leveraging microfluidic and stem cell technologies, we developed an bone-on-a-chip model that enables the dynamic co-culture of osteoblasts (OBs) and osteoclasts (OCs) in a spatiotemporal context. Article Title: Integrin β1 Mediates Mechanosensitive Regulation of Human Trabecular Meshwork Cell Functions in Response to Substrate Stiffness Article Snippet: .. Cells were incubated overnight at 4 °C in a dark humid chamber with primary antibodies against integrin β1 (1:200, MAB2000; Sigma), Blocking Assay:Article Title: Bone-on-a-chip recapitulates dynamic bone remodeling. Article Snippet: Bone remodeling is governed by the basic multicellular unit (BMU) and plays a crucial role in both normal bone function and pathological conditions (e.g. osteoporosis).. Unfortunately, our understanding of the bone remodeling process is limited as current models do not allow dynamic events in the BMU to be systematically and spatiotemporally analyzed.. Leveraging microfluidic and stem cell technologies, we developed an bone-on-a-chip model that enables the dynamic co-culture of osteoblasts (OBs) and osteoclasts (OCs) in a spatiotemporal context. |
